日本語
KEIO UNIVERSITY 
School of Medicine 

AssistantProfessor(Non-tenured) 
Imamura K. Chiyo 

Link to J-GLOBAL(Japanese Only) ]

Career
Japanese Red Cross Kumamoto Hospital  Department of Pharmacy  1989/04-2000/11 
Keio University Hospital  治験管理センター  2002/02-2004/11 
Keio University Hospital  Department of Pharmacy  2004/12-2007/04 
National Cancer Institute, National Institutes of Health  Medical Oncology Branch, Center for Cancer Research  Visiting Scientist  2007/11-2008/12 
Keio University School of Medicine  Department of Clinical Pharmacokinetics and Pharmacodynamics  2009/01-Present 
Keio University Hospital  臨床研究推進センター教育・研修部門  2015-Present 
理化学研究所  イノベーション推進センター杉山特別研究室  客員研究員  2017/01-Present 

Academic Background
Kumamoto University  Faculty of Pharmaceutical Science  1987/03/31  Graduated 
Graduate School of Pharmaceutical Sciences, Kumamoto University  Master's course  Master's course  1989/03/31  Completed 
Graduate School of Pharmaceutical Sciences, Kumamoto University  Doctoral course  Doctoral course  2000/03/31  Completed 

Licenses and Qualifications
Pharmacist  1987/06/27 
JSPHCS-certified Pharmacist  2001/01 
JSPHCS-certified Senior Pharmacist  2001/01 
JSCPT-certified Clinical Research Coordinator  2005/01 
JSCPT-certified Pharmacist  2006/01 
JSPHCS-certified Senior Oncology Pharmacist (JSOP)  2010/01 
JSCPT-certified Senior Pharmacist  2011/01 

Research Areas
Applied pharmacology 

Research Keywords
clinical pharmacology 
individualized medicine 
PK/PD relationship 
anti-cancer drugs 
special population 

Research Themes
Evaluation of blood concentrations of morphine and its metabolites in cancer patients  1988-1991 
Clinical Implications of assessment of total and free phenytoin blood concentrations  1991-1993 
Preparation and evaluation of a suppository dosage form containing omeprazole  1991-1997 
Effectiveness and its prediction of charcoal hemoperfusion treatment based on drug protein binding in drug-overdosed patients  1992-2000 
Blood concentrations of ciclosporin during pregnancy and immediately after delivery in a renal transplant patient  1995-1996 
Relationship between pharmacokinetics and pharmacodynamics of anti-cancer drugs  2007-Present 
Development of individualized medicine based on the determinats of pharmacokinetics  2007-Present 

Funded Research Projects (Competitive Research Funds, etc.)
高齢者がん診療指針策定に必要な基盤整備に関する研究  Research grant  MHLW  Health and Labour Sciences Research Grants  2018-Present 
小児Ph染色体陽性白血病に対するチロシンキナーゼ阻害薬の適正使用に関する研究開発  Commissioned research  AMED  2018/10/15-2021/03/31  革新的がん医療実用化研究事業 
Development of individualized medicine by exposure matching based on key determinant of pharmacokinetics  Research grant  Grant-in-Aid for Scientific Research  2017/04/01-2020/03/31 
非小細胞肺癌患者に対するEGFR-TKIsの治療薬物モニタリング確立のための研究  Research grant  Grant-in-Aid for Scientific Research  2016/04/01-2019/03/31 
治験活性化に資するGCP運用等に関する研究  Research grant  Japan Agency for Medical Research and Development (AMED)  2015/04/01-2016/03/31 
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Research Achievements (Books)
The Role of pharmacist for leukemia treatment: In handbook of leukemia treatment for medical staff.  Imamura CK  白血病治療における薬剤師の役割,270-288  Chugai Igaku Publishing (in Japanese)  2017/10/25 
チームで学ぶ女性がん患者のためのホルモンマネジメント  今村 知世  治療アドヒアランス 252-256  篠原出版新社(東京)  2017/07 
Renal Cell Carcinoma  Imamura CK  Optimization of Therapy by Pharmacokinetic–Pharmacodynamic Analyses, 369-381  Springer  2017/01  978-4-431-55531-5 
抗がん薬の臨床薬理  今村 知世,谷川原 祐介  特殊病態下における抗がん薬の投与 62-69  南山堂(東京)  2015/07/01 
腎臓病薬物療法専門・認定薬剤師テキスト  Imamura Chiyo  腎機能低下患者に対する抗がん薬の適正使用,337-339  じほう(東京)  2013/05/31 
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Research Achievements (Original Articles and Commentaries)
Research paper (scholarly journal)  Single  Therapeutic drug monitoring of monoclonal antibodies: applicability based on their pharmacokinetic properties  Imamura CK  Drug Metabolism and Pharmacokinetics  2019 
Research paper (scholarly journal)  Joint  Individualized dosing of axitinib based on first-dose area under the concentration-time curve for metastatic renal cell carcinoma  Miura Y, Imamura CK, Uchino K, Kishida T, Matsubara N, Shinojima T, Kondo K, Hongo F, Yoshimura K, Tanigawara Y, Toshimi T  Clinical Genitourinary Cancer  2018  10.1016/j.clgc.2018.09.015 
Research paper (scholarly journal)  Joint  Application of PBPK modeling and virtual clinical study approaches to predict the outcomes of CYP2D6 genotype-guided dosing of tamoxifen  Nakamura T, Toshimoto K, Lee W, Imamura CK, Tanigawara Y, Sugiyama Y  CPT Pharmacometrics Syst Pharmacol  7, 474-482  2018  10.1002/psp4.12307 
(MISC) Review or Commentary (other)  Single  Clinical Studies for Development of Individualized Medicine Based on Clinical Pharmacologu  Imamura CK  Japanese Journal of Breast Cancer (in Japanese)  Shinoharashinsya Publishers Inc.  33/ 3, 235-243  2018/06/29 
Research paper (scholarly journal)  Joint  Dynamic changes in CD44v-positive cells after preoperative anti-HER2 therapy and its correlation with pathologic complete response in HER2-positive breast cancer  Yamauchi T, Fernandez JRE, Imamura CK, Yamauchi H, Jinno H, Takahashi M, Kitagawa Y, Nakamura S, Lim B, Krishnamurthy S, Reuben JM, Liu D, Tripathy D, Chen H, Takebe N, Saya H, Ueno NT  Oncotarget  9/ 6, 6872-6882  2018/01/04  10.18632/oncotarget.23914 
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Research Achievements (Oral/Poster Presentations)
Poster presentation  A randomized phase II trial evaluating CYP2D6 genotype-guided tamoxifen dosing in hormone receptor-positive metastatic breast cancer: TARGET-1  ASCO Annual Meeting  2018/06 
Other  免疫チェックポイント阻害薬の薬物動態;スペシャル・ポピュレーションへのアプローチのための基礎知識(教育講演)  第10回日本がん薬剤学会学術大会  2018/05/13 
Oral presentation(general)  Virtual Clinical Studyの適応 -タモキシフェン臨床試験の前向き予測-  日本薬物動態学会第32年会  2017/11 
Symposium workshop panel (nominated)  Clinical profile of approved anticancer drugs  The 55th Annual Meeting of Japan Society of Clinical Oncology  2017/10/20 
Other  Clinical pharmacology of anticancer drugs  The 55th Annual Meeting of Japan Society of Clinical Oncology  2017/10/20 
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Research Achievements (Artistic, Fieldwork, etc.)
Lecture  Single  Exposure-response(PK/PD)relationshipに基づいた抗がん薬の個別化投与  2018/08/26-2018/08/26 
Lecture  Single  PK/PD relationship(Exposure-Response relationship)~小児における応用と今後の展望~  2018/07/11-2018/07/11 
Supervising and cooperating with the media (TV, etc.)  Single  春のふれあい座談会  2017/09-Present  小野薬品工業株式会社MR研修用動画監修 
Lecture  Single  Exposure-response analysis of erlotinib for individualized dosing based on TDM  2017/09/26-2017/09/26 
Lecture  Single  スペシャル・ポピュレーションへのがん薬物療法  2017/09/16-2017/09/16 
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Courses in Charge of
臨床薬剤学(医学部3年生) 
診断学実習(医学部5年生) 
Clinicl Pharmacology (Graduate School of Health Manegement) 
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Social Activities
Institutional Review Board at Shizuoka Cancer Center  2010/04/01-Present 
Institutional Review Board at P1 Clinic  2011/07/01-2013/04 
Journal of Cancer  2010/05/01-Present 
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Memberships in Academic Societies
The Pharmaceutical Society of Japan  1987-Present 
The Japanese Society of Clinical Pharmacology and Therapeutics (JSCPT)  1993-Present 
Japanese Society of Pharmaceutical Health Care and Sciences (JSPHCS)  1999-Present 
The Japanese Society of Therapeutic Drug Monitoring 
The Japanese Society for the Study of Xenobiotics (JSSX)  
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  Link to KOARA(Japanese Only) About KOARA(KeiO Associated Repository of Academic resources)(Japanese Only)
  About KOARA(KeiO Associated Repository of Academic resources)(Japanese Only)