日本語
KEIO UNIVERSITY 
Faculty of Pharmacy 
Department of Pharmaceutical Sciences 

Professor 
SUGAI TAKESHI 

Year of Birth:1959  
http://www.pha.keio.ac.jp/laboratory/laboratory01.html  

Link to J-GLOBAL(Japanese Only) ]

Career
東京大学農学部文部教官助手  1984/04-1988/03 
慶應義塾大学(理工学部)、助手  1988/04-1993/03 
Research Associate, The Scripps Research Institute  1991/08-1992/09 
慶應義塾大学(理工学部)、専任講師  1993/04-1997/03 
茨城大学大学院(生物化学工学特別講義)、非常勤講師  1994/10-1995/03 
慶應義塾大学理工学部(化学科)、助教授  1997/04-2007/03 
横浜国立大学工学部、非常勤講師  1997/04-Present 
慶應義塾大学院理工学研究科基礎理工学専攻幹事  2000/04-2003/03 
東京工業大学大学院理工学研究科化学専攻、非常勤講師  2003/01-2003/01 
慶應義塾大学院理工学研究科基礎理工学専攻学習指導副主任  2005/04-2007/03 
静岡県立大学大学院、非常勤講師  2006/01-2006/01 
東京農工大学大学院、非常勤講師  2006/07-2006/07 
慶應義塾大学理工学部(化学科)、准教授  2007/04-2008/03 
Professor, Faculty of Pharmacy, Keio University  2008/04-Present 
慶應義塾大学薬学部(薬科学科)教授  2011/04-Present 

Academic Background
The University of Tokyo  Faculty of Agriculture  農芸化学科  1981/03/28  Graduated 
The University of Tokyo  Graduate School, Division of Agricultural Science  農芸化学専門課程  Master's course  1983/03/29  Completed 
The University of Tokyo  Graduate School, Division of Agricultural Science  農芸化学専門課程  Doctoral course  1984/03/31  Withdrawal before completion 

Academic Degrees
農学   The University of Tokyo  1987/06/29 

Research Areas
Organic Chemistry 
Synthetic Chemistry 
Catalyst and Chemical Process 
Bioengineering 
Biological Productive Chemistry and Bioorganic Chemistry 

Research Achievements (Books)
“Future Directions in Biocatalysis (Second Edition)”  R. Tsunekawa, K. Hanaya, M. Shoji, T. Sugai  279–295  T. Matsuda, ed., Elsevier  2017/08 
“Comprehensive Organic Synthesis II (Second Edition) Volume 2: Additions to C–X Π-Bonds, Part 2”  T. Sugai, K. Fushuku  512–522  P. Knochel, G. A. Molander, eds., Elsevier  2014/01/01 
Practical Methods for Biocatalysis and Biotransformations  T. Sugai, A. Fujino, H. Yamaguchi, M. Ikunaka  190-198  J. Whittal, P. W. Sutton, eds., Wiley  2009/12/01 
Glycoscience: Chemistry and Chemical Biology  T. Sugai, T. Kajimoto  907-1021  Springer-Verlag GmbH, Berlin Heidelberg New York (B. O. Fraser-Reid, K. Tatsuta, J. Thiem eds.)  2001/12/01  単糖類の化学・酵素合成における最近の進歩について解説した。 
Enzymes in Nonaqueous Solvents; Methods and Protocols, Methods in Biotechnology  401-416  Springer  2001/10/01  界面バイオリアクターを用いる、微生物物質変換反応について著者らの成果を中心に解説した。 
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Research Achievements (Original Articles and Commentaries)
Research paper (scholarly journal)  Joint  Synthesis of Trilobatin from Naringin via Prunin as the Key Intermediate: Acidic Hydrolysis of the α-Rhamnosidic Linkage in Naringin under Improved Conditions  K. Kurahayashi, K. Hanaya, S. Higashibayashi, T. Sugai  Biosci. Biotechnol. Biochem.  82, 1463-1467  2018/09 
Research paper (scholarly journal)  Joint  Synthesis of oroxylin A starting from naturally abundant baicalin  R. Fujita, K. Hanaya, S. Higashibayashi, T. Sugai  Heterocycles  97, 1165-1174  2018/09 
Research paper (scholarly journal)  Joint  Synthesis and Properties of Hydrazine-Embedded Biphenothiazines and Application of Hydrazine-Embedded Heterocyclic Compounds to Fluorescence Cell Imaging  Y. Shindo, S. Nomura, Y. Saikawa, M. Nakata, K. Tanaka, K. Hanaya, T. Sugai, S. Higashibayashi  Asian J. Org. Chem.  7, 1797-1801  2018/08 
Research paper (scholarly journal)  Joint  Hydroxytyrosol butyrate inhibits 6-OHDA-induced apoptosis through activation of the Nrf2/HO-1 axis in SH-SY5Y cells  M. Funakoshi-Tago, T. Sakata, S. Fujiwara, A. Sakakura, T. Sugai, K. Tago, and H. Tamura  Eur. J. Pharmacol.  834, 246-256  2018/05 
Research paper (scholarly journal)  Joint  Synthesis of Fisetin and 2’,4’,6’-Trihydroxydihyrochalcone 4’-O-β-Neohesperidoside Based on Site-Selective Deacetylation and Deoxygenation  R. Tsunekawa, K. Hanaya, S. Higashibayashi, T. Sugai  Biosci. Biotechnol. Biochem.  18, 1316-1322  2018/05 
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Research Achievements (Oral/Poster Presentations)
Oral presentation (invited/special)  Enzyme-catalyzed Asymmetric Reduction of Cyclic Ketoesters and Application to Natural Product Synthesis  The 13th Yonsei CBMH-Keio LCC Joint Symposium  2017/10/13 
Oral presentation (invited/special)  The Complementary and Integrated Chemo-enzymatic Processes for Fine Chemical Syntheses (Invited Lecture)  The 14th Asia Pacific Confederation of Chemical Engineering  2012/02/23  カルバ糖およびDHMEQを題材に、リパーゼによる位置および立体選択的変換について最新の成果を報告した。 
Oral presentation(general)  Chemo-enzymatic approaches towards both enatiomers of dehydroxymethylepoxy-quinomicin (DHMEQ) (Selected Oral Presentation)  10th International Symposium on Biocatalysis and Biotransformations  2011/10/06  DHMEQを題材に、リパーゼによる位置および立体選択的変換について最新の成果を報告した。 
Oral presentation (invited/special)  Regio- and stereoselective lipase-catalyzed reactions on sugars and carbasugars (Invited Lecture)  The International Chemical Congress of Pacific Basin Societies  2010/12/19  glucal誘導体およびカルバ糖、さらにはDHMEQを題材に、リパーゼによる位置および立体選択的変換について最新の成果を報告した。 
Oral presentation (invited/special)  Recognition of Remote Chiral Centers in the Course of Lipase-Catalyzed Resolution and Its Application to Both Enantiomers of TBMB Acid (Invited Lecture)  BIT's Inaugural Symposium on Enzymes & Biocatalysis  2010/04/24  TBMBカルボン酸を題材に、リパーゼによる遠隔不斉中心立体認識、微生物不斉還元と化学合成を組み合わせる手法について概説した。 
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Awards
Presidential 2000 Green Chemistry Challenge Award, as a co-recipient of the honoring C.-H. Wong  Enzymes in Large-scale Organic Synthesis  2000/06 
農芸化学奨励賞  生体触媒を利用する不斉合成と物質生産への応用  1994/04 
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Social Activities
化学情報協会  2001/04-2002/03 
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Memberships in Academic Societies
Current Organic Synthesis  2003/01-Present 
Mini-Reviews in Organic Chemistry  2003/01-Present 
日本化学会  2004/04/01-Present 
日本農芸化学会  2001/03-Present 
日本糖質学会  1999/04-Present 
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Committee Experiences
Current Organic Synthesis  Editorial Advisory Board  2003/01-Present 
Mini-Reviews in Organic Chemistry  Editorial Advisory Board  2003/01-Present 
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  About KOARA(KeiO Associated Repository of Academic resources)(Japanese Only)