日本語
KEIO UNIVERSITY 
Faculty of Pharmacy 
Department of Pharmacy 

Assistant Professor / Research Associate / Instructor 
NAGANUMA Tatsuro 

Year of Birth:1986  
Telephone No.03-5400-2492  
 

Link to J-GLOBAL(Japanese Only) ]

Career
理化学研究所  生命医科学研究センター メタボローム研究チーム  基礎科学特別研究員  2016/04/01-2016/07/31 
理化学研究所  生命医科学研究センター メタボローム研究チーム  客員研究員  2016/08/01-Present 
慶應義塾大学  薬学部 代謝生理化学講座  助教  2016/08/01-Present 

Academic Background
北海道大学  薬学部  薬学科  2012/03  Graduated 
北海道大学  大学院生命科学院  臨床薬学専攻  Doctoral course  2016/03  Graduated 

Licenses and Qualifications
薬剤師 

Profile Summary
Varieties of the lipid molecules are involved in the maintenance of skin homeostasis by exerting their characteristic bioactivities or physiological functions. For instance, ceramide species themselves form hydrophobic barrier which is indispensable for skin barrier function, or one of ω3 fatty acid-derived lipid mediator can resolve skin inflammation. Then, to clarify the cause of cutaneous disorders, we should globally understand the whole lipid profiles in disease onset.
I’m performing the lipidomics using LC-MS/MS in various models of skin disorders such as atopic dermatitis, psoriasis, and contact dermatitis to unveil the molecular machinery underlying each pathology. Moreover, I’m trying to find new lipid metabolites and their physiological functions which are responsible for the maintenance of skin homeostasis. 

Research Areas
Biological pharmacy 

Research Keywords
脂質,生化学,メタボローム,皮膚,酸化リン脂質 

Funded Research Projects (Competitive Research Funds, etc.)
皮膚疾患の発症に関わる脂質代謝系のマルチオミクス解析  Research grant  セコム科学技術振興財団  挑戦的研究助成  2017/04/01-2020/03/31 
皮膚恒常性に関わる脂質代謝系の包括的理解を目指した網羅的メタボローム解析  Research grant  日本学術振興会  Grant-in-Aid for Scientific Research  2017/04/01-2019/03/31 
皮膚炎発症の抑制に関わる脂肪酸代謝物の探索と分子メカニズムの解析  Research grant  慶應義塾大学  Keio Gijuku Academic Development Funds  2017/04/01-2018/03/31 
ω3脂肪酸による皮膚恒常性制御機構の解析  Research grant  慶應義塾大学  Keio Gijuku Fukuzawa Memorial Fund for the Advancement of Education and Research  2017/04/01-2018/03/31 
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Research Achievements (Original Articles and Commentaries)
Research paper (scholarly journal)  Joint  Decreased skin barrier lipid acylceramide and differentiation-dependent gene expression in ichthyosis gene Nipal4 knockout mice.  Honda Y, Kitamura T, Naganuma T, Abe T, Ohno Y, Sassa T, Kihara A.  J Invest Dermatol  138, 741-749  2018/04 
Joint  脂肪酸クオリティと炎症・アレルギーの制御  永沼 達郎 有田 誠  炎症と免疫  先端医学社  25/ 4  2017/06/20 
Research paper (scholarly journal)  Disruption of the Sjogren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery  Naganuma Tatsuro, Takagi Shuyu, Kanetake Tsukasa, Kitamura Takuya, Hattori Satoko, Miyakawa Tsuyoshi, Sassa Takayuki, Kihara Akio  JOURNAL OF BIOLOGICAL CHEMISTRY  291/ 22, 11676-11688  2016/05  0021-9258  10.1074/jbc.M116.714030 
Research paper (scholarly journal)  Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases  Narita Tomomi, Naganuma Tatsuro, Sase Yurie, Kihara Akio  SCIENTIFIC REPORTS  6, 1395-1401  2016/05  2045-2322  10.1038/srep25469 
Research paper (scholarly journal)  Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification  Kitamura Takuya, Takagi Shuyu, Naganuma Tatsuro, Kihara Akio  BIOCHEMICAL JOURNAL  465, 79-87  2015/01  0264-6021  10.1042/BJ20140624 
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Research Achievements (Oral/Poster Presentations)
Oral presentation (invited/special)  皮膚の網羅的リピドミクスと疾患モデルへの適用  第11回セラミド研究会学術集会  2018/10/26 
Oral presentation(general)  Untargeted analysis of skin lipid profiles in the development of dermatitis  Japan-Korea Joint Lipid Symposium  2018/09/14 
Oral presentation(general)  アトピー性皮膚炎マウスにおける脂質代謝異常の網羅的解析  第17回次世代を担う若手ファーマ・バイオフォーラム2018  2018/09/01 
Oral presentation(general)  皮膚のリポクオリティの包括的解析とアトピー性皮膚炎モデルへの適用  新学術領域研究「脂質クオリティが解き明かす生命現象」第4回班会議  2018/06/18 
Oral presentation(general)  アトピー性皮膚炎発症に関わる脂質代謝系の網羅的メタボローム解析  第60回日本脂質生化学会  2018/05/31 
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Courses in Charge of
卒業研究 
卒業研究A 
薬科学英語演習V 
薬学英語演習V 
代謝生化学 
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Memberships in Academic Societies
セラミド研究会 
日本生化学会 
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