日本語
KEIO UNIVERSITY 
Faculty of Pharmacy 
Department of Pharmacy 

Assistant Professor / Research Associate / Instructor 
NAGANUMA Tatsuro 

Year of Birth:1986  
Telephone No.03-5400-2492  
 

Link to J-GLOBAL(Japanese Only) ]

Career
理化学研究所  統合生命医科学研究センター メタボローム研究チーム  基礎科学特別研究員  2016/04/01-2016/07/31 
理化学研究所  統合生命医科学研究センター メタボローム研究チーム  客員研究員  2016/08/01-Present 
慶應義塾大学  薬学部 代謝生理化学講座  助教  2016/08/01-Present 

Academic Background
北海道大学  薬学部  薬学科  2012/03  Graduated 
北海道大学  大学院生命科学院  臨床薬学専攻  Doctoral course  2016/03  Graduated 

Licenses and Qualifications
薬剤師 

Profile Summary
Varieties of the lipid molecules are involved in the maintenance of skin homeostasis by exerting their characteristic bioactivities or physiological functions. For instance, ceramide species themselves form hydrophobic barrier which is indispensable for skin barrier function, or one of ω3 fatty acid-derived lipid mediator can resolve skin inflammation. Then, to clarify the cause of cutaneous disorders, we should globally understand the whole lipid profiles in disease onset.
I’m performing the lipidomics using LC-MS/MS in various models of skin disorders such as atopic dermatitis, psoriasis, and contact dermatitis to unveil the molecular machinery underlying each pathology. Moreover, I’m trying to find new lipid metabolites and their physiological functions which are responsible for the maintenance of skin homeostasis. 

Research Areas
Biological pharmacy 

Research Keywords
脂質,生化学,メタボローム,皮膚,酸化リン脂質 

Funded Research Projects (Competitive Research Funds, etc.)
皮膚疾患の発症に関わる脂質代謝系のマルチオミクス解析  Research grant  セコム科学技術振興財団  挑戦的研究助成  2017/04/01-2020/03/31 
皮膚恒常性に関わる脂質代謝系の包括的理解を目指した網羅的メタボローム解析  Research grant  日本学術振興会  Grant-in-Aid for Scientific Research  2017/04/01-2019/03/31 
皮膚炎発症の抑制に関わる脂肪酸代謝物の探索と分子メカニズムの解析  Research grant  慶應義塾大学  Keio Gijuku Academic Development Funds  2017/04/01-2018/03/31 
ω3脂肪酸による皮膚恒常性制御機構の解析  Research grant  慶應義塾大学  Keio Gijuku Fukuzawa Memorial Fund for the Advancement of Education and Research  2017/04/01-2018/03/31 
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Research Achievements (Original Articles and Commentaries)
Joint  脂肪酸クオリティと炎症・アレルギーの制御  永沼 達郎 有田 誠  炎症と免疫  先端医学社  25/ 4  2017/06/20 
Research paper (scholarly journal)  Disruption of the Sjogren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery  Naganuma Tatsuro, Takagi Shuyu, Kanetake Tsukasa, Kitamura Takuya, Hattori Satoko, Miyakawa Tsuyoshi, Sassa Takayuki, Kihara Akio  JOURNAL OF BIOLOGICAL CHEMISTRY  291/ 22, 11676-11688  2016/05  0021-9258  10.1074/jbc.M116.714030 
Research paper (scholarly journal)  Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases  Narita Tomomi, Naganuma Tatsuro, Sase Yurie, Kihara Akio  SCIENTIFIC REPORTS  6, 1395-1401  2016/05  2045-2322  10.1038/srep25469 
Research paper (scholarly journal)  Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification  Kitamura Takuya, Takagi Shuyu, Naganuma Tatsuro, Kihara Akio  BIOCHEMICAL JOURNAL  465, 79-87  2015/01  0264-6021  10.1042/BJ20140624 
Research paper (scholarly journal)  Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids  Kondo Natsuki, Ohno Yusuke, Yamagata Maki, Obara Takashi, Seki Naoya, Kitamura Takuya, Naganuma Tatsuro, Kihara, Akio  NATURE COMMUNICATIONS  5, 11676-11688  2014/10  2041-1723  10.1038/ncomms6338 
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Research Achievements (Oral/Poster Presentations)
Oral presentation(general)  Skin Homeostasis and Lipid Metabolism  University of Strasbourg-RIKEN Workshop on Membrane Lipidology  2017/03/09 
Oral presentation(general)  Retarded skin barrier recovery and an increased keratinocyte growth in Sjögren-Larsson syndrome gene ALDH3A2 knockout mice.  1st Korea-Japan Bioactive Lipid Joint Symposium  2016/05/11 
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Courses in Charge of
実験法概論 
代謝生化学 
機能生理学2 
システム生体機能学特論 
生物系薬学特論II 
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Memberships in Academic Societies
セラミド研究会 
日本生化学会 
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