日本語
KEIO UNIVERSITY 
Faculty of Pharmacy 
Department of Pharmaceutical Sciences 

Professor 
OSAWA MASANORI 

Research Areas
Structural biochemistry 
Biophysics 

Research Keywords
structural biology 
nuclear magnetic resonance 
membrane protein 
ion channel 
translation factor 
Signal transduction 

Research Achievements (Books)
【試料分析講座】「蛋白質の分析」  OSAWA MASANORI  NMR・CDスペクトル  分析化学会(丸善)  2012 
分子細胞生物学辞典 (第2版)  OSAWA MASANORI  「等温滴定型カロリメトリー」,「滴定曲線」  東京化学同人  2008 
実験医学別冊「生命科学のための機器分析実験ハンドブック」  OSAWA MASANORI  「等温滴定型カロリメトリー(ITC) ~熱量測定による相互作用の定量的解析~」  羊土社  2007 
「物理系薬学」 III. 生体分子・化学物質の構造決定  OSAWA MASANORI  「SBO15 タンパク質の自由度について概説できる」  東京化学同人  2005 
ゲノム創薬・創薬のパラダイムシフト  OSAWA MASANORI  構造生物学に基づく創薬分子デザイン  2001 
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Research Achievements (Original Articles and Commentaries)
Joint  Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR  Tatsuro Maruyama, Shunsuke Imai, Tsukasa Kusakizako, Motoyuki Hattori, Ryuichiro Ishitani, Osamu Nureki, Koichi Ito, Andrès D Maturana, Ichio Shimada, Masanori Osawa  eLIFE  2018/04 
Research paper (scholarly journal)  Joint  Structural basis for the ethanol action on G-protein–activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy  Yuki Toyama, Hanaho Kano, Yoko Mase, Mariko Yokogawa, Masanori Osawa and Ichio Shimada  PNAS  2018/03/26  https://doi.org/10.1073/pnas.1722257115 
Research paper (scholarly journal)  Joint  Multimeric structure of poly(A)-binding protein on a poly(A) tail.  Sawazaki R, Imai S, Yokogawa M, Hosoda N, Hoshino S, Mio M, Mio K, Shimada I, Osawa M,  Sci. Rep.  8, 1455  2018/01/23 
Research paper (scholarly journal)  Nuclear Magnetic Resonance Approaches for Characterizing Protein-Protein Interactions  Yuki Toyama, Yoko Mase, Hanaho Kano, Mariko Yokogawa, Masanori Osawa, Ichio Shimada  Methods Mol Biol.  1684, 115-128  2017/10/21 
Research paper (scholarly journal)  Molecular mechanism of the ATP-dependent modulation of the Mg2+ channel MgtE for Mg2+ homeostasis  Tomita A, Zhang M, Jin F, Zhuang W, Takeda H, Maruyama T, Osawa M, Hashimoto KI, Kawasaki H, Ito K, Dohmae N, Ishitani R, Shimada I, Yan Z, Hattori M, Nureki O.  Nat Commun  8/ 1, 148  2017/08  10.1038/s41467-017-00082-w 
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Research Achievements (Oral/Poster Presentations)
Oral presentation(general)  Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR.  第57回NMR討論会  2018/09/18 
Oral presentation (invited/special)  溶液NMR 法によるMg2+ チャネルMgtE の開閉機構の解明  大阪大学蛋白質研究所セミナー  2018/09/03  URL 
Poster presentation  Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail.  第18回 日本蛋白質科学会年会  2018/06/28  URL 
Oral presentation(general)  Structural dynamics of potassium ion channels revealed by side-chain methyl13C-1H multiple quantum relaxation analyses.  59th Experimental Nuclear Magnetic Resonance Conference  2018/04/29 
Poster presentation  Elucidation of the structural mechanism for the gating of a voltage-dependent K+ channel, hERG, by stabilizing its closed state  138th Annual Meeting of the Pharmaceutical Society of Japan  2018/03/26 
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Awards
Best Poster Award  Structural Basis for the Inhibition of Voltage-dependent K+ Channel by Gating Modifier Toxin  2016/07/12 
長瀬研究振興賞  Development of novel nanodisc that enables solution NMR analyses of membrane protein interactions in the lipid bilayer  2016/04/01 
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Courses in Charge of
Analytical Chemistry 
Basic pharmaceutical sciences laboratory course 
物理分析学 
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