日本語
KEIO UNIVERSITY 
Faculty of Pharmacy 
Department of Pharmacy 

Assistant Professor / Research Associate / Instructor 
ICHIKAWA Daiju 

Research Achievements (Original Articles and Commentaries)
Research paper (scholarly journal)  Joint  A novel derivative (GTN024) from a natural product, komaroviquinone, induced the apoptosis of high-risk myeloma cells via reactive oxygen production and ER stress.  Okayama M, Kitabatake S, Sato M, Fujimori K, Ichikawa D, Matsushita M, Suto Y, Iwasaki G, Yamada T, Kiuchi F, Hirao M, Kunieda H, Osada M, Okamoto S, Hattori Y  Biochem Biophys Res Commun.  505/ 3, 787-793  2018/11/02  10.1016/j.bbrc.2018.09.177. 
Research paper (scholarly journal)  Joint  Early Generated B-1-Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma-like Neoplasia in Aged Mice.  Hayakawa K, Formica AM, Nakao Y, Ichikawa D, Shinton SA, Brill-Dashoff J, Smith MR, Morse HC 3rd, Hardy RR.  J Immunol.  201/ 2, 804-813  2018/07/15  doi: 10.4049/jimmunol.1800400. 
Research paper (scholarly journal)  Joint  NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome.  ICHIKAWA Daiju  J Exp Med.  2017/09/06  10.1084/jem.20170497 
Research paper (scholarly journal)  Joint  A novel phenylphthalimide derivative, pegylated TC11, improves pharmacokinetic properties and induces apoptosis of high-risk myeloma cells via G2/M cell-cycle arrest.  ICHIKAWA Daiju  Biochem Biophys Res Commun.  2017/09/01  10.1016/j.bbrc.2017.08.159 
Research paper (scholarly journal)  Joint  Synthesis and biological evaluation of the natural product komaroviquinone and related compounds aiming at a potential therapeutic lead compound for high-risk multiple myeloma.  ICHIKAWA Daiju  Bioorg Med Chem Lett.  2017/08/30  10.1016/j.bmcl.2017.08.054 
View details...

Research Achievements (Oral/Poster Presentations)
Poster presentation  Elucidation of the IMiDs-Resistant Mechanism and Development of the Overcoming Drugs Inducing CRBN Independent G2/M Cell Cycle Arrest in Myeloma Cells.  60th AMERICAN SOCIETY of HEMATOLOGY Annual Meeting and Exposition.  2018/12/03 
Poster presentation  Immunomodulatory Effects of Proteasome Inhibitors in Multiple Myeloma.  60th AMERICAN SOCIETY of HEMATOLOGY Annual Meeting and Exposition.  2018/12/01 
Oral presentation(general)  新規天然化合物コマロビキノン化合物の抗骨髄腫効果および構造展開  第80回日本血液学会学術集会  2018/10/14 
プロテアソーム阻害薬の免疫原性細胞死による免疫調節機能  第80回日本血液学会学術集会  2018/10/14 
Poster presentation  多発性骨髄腫のIMIDs抵抗性メカニズムの解明  第77回日本癌学会学術集会  2018/09/27 
View details...