日本語
KEIO UNIVERSITY 
Faculty of Pharmacy 
Department of Pharmaceutical Sciences 

Assistant Professor / Research Associate / Instructor 
HANAYA Kengo 

Year of Birth:1984  

Funded Research Projects (Competitive Research Funds, etc.)
スルホン酸エステルを母核とした刺激応答性リンカーの開発とプロドラッグへの応用  Research grant  JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE  Grant-in-Aid for Scientific Research  2016/04/01-2019/03/31 
刺激応答性リンカーの創製に向けたアミノスルホン酸エステルの分子内環化反応の開発  Research grant  THE JAPAN SCIENCE SOCIETY  SASAKAWA SCIENTIFIC RESEARCH GRANT  2016/04/01-2017/03/31 
酵素触媒を活用した不斉誘導体化試薬の創製 (超高感度化と効率的供給法の開発)  Research grant  日本私立学校振興・共済事業団  The Science Research Promotion Fund  2015/04/01-2016/03/31 
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Research Achievements (Original Articles and Commentaries)
Research paper (scholarly journal)  Joint  Synthesis of 3β-tert-Butyldimethylsiloxy-22-phenylthio-23,24-bisnorchola-5,9(11)-diene and Reductive Nucleophilic Attack on a Branched Aliphatic Aldehyde  NAGAI Toshiya, HANAYA Kengo, HIGASHIBAYASHI Shuhei, SHOJI, Mitsuru, SUGAI Takeshi  CHEMICAL and PHARMACEUTICAL BULLETIN  66, 334-338  2018  10.1248/cpb.c17-00979 
Research paper (scholarly journal)  Joint  Synthesis of fisetin and 2',4',6'-trihydroxydihyrochalcone 4'-O-β-neohesperidoside based on site-selective deacetylation and deoxygenation  TSUNEKAWA Ryuji, HANAYA Kengo, HIGASHIBAYASHI Shuhei, SUGAI Takeshi  Bioscience, Biotechnology, and Biochemistry  82, 1316-1322  2018  10.1080/09168451.2018.1467263 
Research paper (scholarly journal)  Joint  Synthesis of trilobatin from naringin via prunin as the key intermediate: acidic hydrolysis of the α-rhamnosidic linkage in naringin under improved conditions  KURAHAYASHI Kazuki, HANAYA Kengo, HIGASHIBAYASHI Shuhei, SUGAI Takshi  Bioscience, Biotechnology, and Biochemistry  82, 1463-1467  2018  10.1080/09168451.2018.1482455. 
Research paper (scholarly journal)  Joint  A vinylogous photocleavage strategy allows direct photocaging of backbone amide structure.  MAGUBAT-MEDINA Alicia E,MARTIN Samuel C,HANAYA Kengo, BALL Zachary T  Journal of the American Chemical Society  American Chemical Society  140, 8401-8404  2018/06/20  10.1021/jacs.8b04893 
Research paper (scholarly journal)  Joint  Formal total synthesis of (−)-hamigeran B from a chemo-enzymatically prepared building block with quaternary chiral center  KUWATA Kazuaki, FUJITA Rie, HANAYA Kengo, HIGASHIBAYASHI Shuhei, SUGAI Takeshi  Tetrahedron  74/ 7, 740-745  2018/02/15 
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Research Achievements (Oral/Poster Presentations)
Poster presentation  Development of enzyme-activatable sulfonate-based prodrugs for active targeting therapy  ICC05-AEM2016  2016/09/06 
Poster presentation  Development of artificial molecular catalyst for hybrid enzymes  ICC05-AEM2016  2016/09/06 
Oral presentation (invited/special)  Development of Aminosulfonate Ester-based Self-immolative linker for Application in Prodrug  International Symposium on Pure & Applied Chemistry (ISPAC) 2016  2016/08/17 
Poster presentation  Development of self-immolative aminosulfonate linker for prodrug  17th Tetrahedron Symposium  2016/06/28 
Poster presentation  5-8-5員環骨格を有するテルペノイドの合成研究  日本薬学会第136年会  2016/03/28 
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