Research Achievements (Original Articles and Commentaries)
Number of the published data : 29     Download a complete list of all data (tab-deliminated text format)
No. Type of Paper Single/Joint Authorship Title Author(s) Journal Publisher Volume/Issue/Page Publication Date ISSN DOI URL Summary Related information
1

A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis

Niino Tomomi, Tago K...Detail
Biochemical Pharmacology

155, 182-197
2018/09/01
0006-2952
https://doi.org/10.1016/j.bcp.2018.06.021

<p>5-Hydroxyoxindole is a urinary metabolite of indole that exhibits antioxidant activity. In ...Detail

2

Hit-to-Lead in Academia

Yasuda Daisuke, Obat...Detail
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

138/ 8, 1059-1065
2018/01/01
0031-6903
https://doi.org/10.1248/yakushi.17-00211-5

<p> In the process of recent hit-to-lead studies, not only in industry but also in academia, ...Detail

3

Strategic drug design to avoid the metabolic activation of hepatotoxic drugs

Ohe Tomoyuki, Takaha...Detail
Yakugaku Zasshi

137/ 3, 249-255
2017
0031-6903
https://doi.org/10.1248/yakushi.16-00230-1

<p>Adverse reactions are one of the most important issues in drug development, as well as in t...Detail

4

Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor

Yasuda Daisuke, Yuas...Detail
Bioorganic and Medicinal Chemistry Letters

27/ 22, 5006-5009
2017/11/15
0960-894X
https://doi.org/10.1016/j.bmcl.2017.10.008

<p>The Keap1-Nrf2 system is an attractive target for drug discovery regarding various unmet me...Detail

5

Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity

Yasuda Daisuke, Naka...Detail
Bioorganic and Medicinal Chemistry Letters

26/ 24, 5956-5959
2016/12/15
0960-894X
https://doi.org/10.1016/j.bmcl.2016.10.083

<p>The Keap1-Nrf2 system is involved not only in biological defense but also in malignancy pro...Detail

6

Preparation and antioxidant/pro-oxidant activities of 3-monosubstituted 5-hydroxyoxindole derivatives

Yasuda Daisuke, Taka...Detail
Cleft Palate-Craniofacial Journal

59/ 6, 165-173
2016/11/01
1055-6656
https://doi.org/10.3164/jcbn.16-24

<p>Antioxidant treatments have been expected to be a novel thera-peutics for various oxidative...Detail

7

Novel fullerene derivatives as dual inhibitors of Hepatitis C virus NS5B polymerase and NS3/4A protease

Kataoka Hiroki, Ohe ...Detail
Bioorganic and Medicinal Chemistry Letters

26/ 19, 4565-4567
2016/10/01
0960-894X
https://doi.org/10.1016/j.bmcl.2016.08.086

<p>We evaluated the Hepatitis C virus (HCV) NS5B polymerase and HCV NS3/4A protease inhibition...Detail

8 Research paper (scholarly journal)
Joint
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

Saito T, Ichimura Y,...Detail
Nature Communications

7/ 12030, 1-16
2016/01





9

Novel bioactivation pathway of benzbromarone mediated by cytochrome P450

Kitagawara Yumina, O...Detail
Drug Metabolism and Disposition

43/ 9, 1303-1306
2015/09/01
0090-9556
https://doi.org/10.1124/dmd.115.065037

<p>Benzbromarone (BBR) is a hepatotoxic drug, but the detailed mechanism of its toxicity remai...Detail

10

The human immunodeficiency virus-reverse transcriptase inhibition activity of novel pyridine/pyridinium-type fullerene derivatives

Yasuno Takumi, Ohe T...Detail
Bioorganic and Medicinal Chemistry Letters

25/ 16, 3226-3229
2015/07/03
0960-894X
https://doi.org/10.1016/j.bmcl.2015.05.086

<p>Abstract In the present study, we describe the synthesis of a novel set of pyridine/pyridin...Detail

11

Antioxidant activities of 5-hydroxyoxindole and its 3-hydroxy-3-phenacyl derivatives

Yasuda Daisuke, Taka...Detail
Bioorganic and Medicinal Chemistry

21/ 24, 7709-7714
2013/12/15
0968-0896
https://doi.org/10.1016/j.bmc.2013.10.021

<p>The antioxidant activities of 5-hydroxyoxindole (1) and newly synthesized 3,5-dihydroxy-3-p...Detail

12

Synthesis, radical scavenging activity and structure-activity relationship of uric acid analogs

Yasuda Daisuke, Taka...Detail
MedChemComm

4/ 3, 527-529
2013/03
2040-2503
https://doi.org/10.1039/c2md20287e

<p>Uric acid (UA) is known to play an important role as an endogenous antioxidant. However, it...Detail

13

Ipso substitution of bisphenol A catalyzed by microsomal cytochrome P450 and enhancement of estrogenic activity

Nakamura Shigeo, Tez...Detail
Toxicology Letters

203/ 1, 92-95
2011/05/30
0378-4274
https://doi.org/10.1016/j.toxlet.2011.03.010

<p>Bisphenol A (BPA), an industrial chemical with estrogenic activity, was investigated as a s...Detail

14

Interprofessional education at the Keio University Faculty of Pharmacy

Ehara Yoshihiro, Abe...Detail


57-63
2010

https://doi.org/10.1007/978-4-431-98076-6_6

<p>As part of a trial course on interprofessional education (IPE) at Keio University our Facul...Detail

15

Pyrrolidinium-type fullerene derivative-induced apoptosis by the generation of reactive oxygen species in HL-60 cells

Nishizawa Chiho, Has...Detail
Free Radical Research

43/ 12, 1240-1247
2009
1071-5762
https://doi.org/10.3109/13814780903260764

<p>The biological activities of C60-bis(N,N-dimethylpyrrolidinium iodide), a water-soluble cat...Detail

16 Research paper (scholarly journal)
Joint
In vitro free radical scavenging activity of platinum nanoparticles.

Watanabe A, Kajita M...Detail
Nanotechnology

20, 455105 (9pp)
2009/10





17

Licochalcone A is a potent inhibitor of TEL-Jak2-mediated transformation through the specific inhibition of Stat3 activation

Funakoshi-Tago Megum...Detail
Biochemical Pharmacology

76/ 12, 1681-1693
2008/12/15
0006-2952
https://doi.org/10.1016/j.bcp.2008.09.012

<p>Aberrant activation of Jak/Stat signaling causes a number of hematopoietic disorders and on...Detail

18

2,2′-Pyridoin derivatives protect HL-60 cells against oxidative stress

Hatanaka Masashi, Ni...Detail
Bioorganic and Medicinal Chemistry Letters

18/ 19, 5290-5293
2008/10/01
0960-894X
https://doi.org/10.1016/j.bmcl.2008.08.057

<p>Focusing on 2,2′-pyridoin (1, 1,2-di(2-pyridyl)-1,2-ethenediol) and its synthetic derivati...Detail

19

Novel metabolic pathways of p-n-nonylphenol catalyzed by cytochrome P450 and estrogen receptor binding activity of new metabolites

Tezuka Yoshito, Taka...Detail
Journal of Health Science

53/ 5, 552-561
2007/10
1344-9702
https://doi.org/10.1248/jhs.53.552

<p>Nonylphenol, which is used industrially as a surfactant, is an endocrine-disrupting chemica...Detail

20 Research paper (research society, symposium material, etc.)
Joint
Synthesis of novel amino acid-type fullerenes and their inhibition activity of HIV reverse transcriptase and HCV RNA polymerase.

Nakamura S, Ikegami ...Detail
J Kyoritsu Univ Pharm

1, 77-84
2006/03





21

Metabolic conversion of 24-methyl-Δ25-cholesterol to 24-methylcholesterol in higher plants

Takahashi Kyoko, Nas...Detail
Bioorganic and Medicinal Chemistry

14/ 3, 732-738
2006/02/01
0968-0896
https://doi.org/10.1016/j.bmc.2005.08.061

<p>Feeding of chemically synthesized [27-13C]codisterol ([27- 13C]2), [2...Detail

22

Preparation and antioxidant activity of α-pyridoin and its derivatives

Hatanaka Masashi, Ta...Detail
Bioorganic and Medicinal Chemistry

13/ 24, 6763-6770
2005/12/15
0968-0896
https://doi.org/10.1016/j.bmc.2005.07.065

<p>Focusing on α-pyridoin (1, 1,2-di(2-pyridyl)-1,2-ethenediol) as the lead compound of the no...Detail

23 Research paper (scholarly journal)
Single
細胞内でホルムアルデヒドを放出する抗がん剤.

高橋恭子.

ファルマシア
/日本薬学会
41, 1099
2005/11





24

Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives

Mashino Tadahiko, Sh...Detail
Bioorganic and Medicinal Chemistry Letters

15/ 4, 1107-1109
2005/02/15
0960-894X
https://doi.org/10.1016/j.bmcl.2004.12.030

<p>We examined the human immunodeficiency virus-reverse transcriptase and hepatitis C virus RN...Detail

25

Antibacterial and antiproliferative activity of cationic fullerene derivatives

Mashino Tadahiko, Ni...Detail
Bioorganic and Medicinal Chemistry Letters

13/ 24, 4395-4397
2003/12/15
0960-894X
https://doi.org/10.1016/j.bmcl.2003.09.040

<p>We examined the antibacterial and antiproliferative activities of alkylated C60-...Detail

26 Research paper (research society, symposium material, etc.)
Joint
Biosynthesis of phytoecdysteroids in Ajuga hairy roots: Clerosterol as a precursor of cyasterone, isocyasterone and 29-norcyasterone.

Okuzumi K, Hara N, F...Detail
Tetrahedron Lett

44, 323-326
2003/02





27

Stereochemistry of reduction of the C-24,25 double bond in the conversion of desmosterol into cholesterol

Takahashi Kyoko, Has...Detail
Tetrahedron Letters

44/ 2, 341-344
2003/01/06
0040-4039
https://doi.org/10.1016/S0040-4039(02)02567-4

<p>Feeding of the chemically prepared [24-13C, 24-2H]desmosterol to cell...Detail

28

Biosynthesis of sterols and ecdysteroids in Ajuga hairy roots

Fujimoto Yoshinori, ...Detail
Lipids

35/ 3, 279-288
2000
0024-4201


<p>Hairy roots of Ajuga reptans var. atropurpurea produce clerosterol, 22- dehydroclerosterol,...Detail

29

Stereochemical fate of C-26 and C-27 during the conversion of isofucosterol to sitosterol and of 24-methylenecholesterol to campesterol and dihydrobrassicasterol in Oryza sativa cell cultures

Nasu Kozue, Takahash...Detail
Phytochemistry

54/ 4, 381-385
2000/06/01
0031-9422
https://doi.org/10.1016/S0031-9422(00)00122-9

<p>Administration of pro-R-methyl-13C-labeled isofucosterol to cultured cells of Or...Detail