日本語
KEIO UNIVERSITY 
Faculty of Pharmacy 
Department of Pharmaceutical Sciences 

Assistant Professor / Research Associate / Instructor 
TAKAHASHI Kyoko 

Telephone No.03-5400-2664  
Fax No.03-5400-2691  
 

Link to J-GLOBAL(Japanese Only) ]

Academic Background
Kyoritsu University of Pharmacy  Faculty of Pharmaceutical Science  1986/03/15  Graduated 

Research Areas
Chemical pharmacy 
Drug development chemistry 

Research Themes
抗酸化活性化合物の合成とデザイン  2002/04/01-Present 
パーキンソン病治療薬の創製  2012-Present 

Research Achievements (Books)
Interprofessional Education at the Keio University Faculty of Pharmacy, in: Advanced Initiatives in Interprofessional Education in Japan" (ed. by Watanabe H, Koizumi M)."  Ehara Y, Abe Y, Fujimoto K, Fukushima N, Iijima S, Ishikawa S, Kishimoto K, Mochizuki M, Takahashi K, Yokota E, Kobayashi S.  pp57-63  Springer, Tokyo, Berlin, Heidelberg, New York  2010/02 
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Research Achievements (Original Articles and Commentaries)
A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis  Niino Tomomi, Tago Kenji, Yasuda Daisuke, Takahashi Kyoko, Mashino Tadahiko, Tamura Hiroomi, Funakoshi-Tago Megumi  Biochemical Pharmacology  155, 182-197  2018/09/01  0006-2952  https://doi.org/10.1016/j.bcp.2018.06.021 
Hit-to-Lead in Academia  Yasuda Daisuke, Obata Rika, Takahashi Kyoko, Ohe Tomoyuki, Mashino Tadahiko  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan  138/ 8, 1059-1065  2018/01/01  0031-6903  https://doi.org/10.1248/yakushi.17-00211-5 
Strategic drug design to avoid the metabolic activation of hepatotoxic drugs  Ohe Tomoyuki, Takahashi Kyoko, Nakamura Shigeo, Mashino Tadahiko  Yakugaku Zasshi  137/ 3, 249-255  2017  0031-6903  https://doi.org/10.1248/yakushi.16-00230-1 
Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor  Yasuda Daisuke, Yuasa Akihiro, Obata Rika, Nakajima Mao, Takahashi Kyoko, Ohe Tomoyuki, Ichimura Yoshinobu, Komatsu Masaaki, Yamamoto Masayuki, Imamura Riyo, Kojima Hirotatsu, Okabe Takayoshi, Nagano Tetsuo, Mashino Tadahiko  Bioorganic and Medicinal Chemistry Letters  27/ 22, 5006-5009  2017/11/15  0960-894X  https://doi.org/10.1016/j.bmcl.2017.10.008 
Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity  Yasuda Daisuke, Nakajima Mao, Yuasa Akihiro, Obata Rika, Takahashi Kyoko, Ohe Tomoyuki, Ichimura Yoshinobu, Komatsu Masaaki, Yamamoto Masayuki, Imamura Riyo, Kojima Hirotatsu, Okabe Takayoshi, Nagano Tetsuo, Mashino Tadahiko  Bioorganic and Medicinal Chemistry Letters  26/ 24, 5956-5959  2016/12/15  0960-894X  https://doi.org/10.1016/j.bmcl.2016.10.083 
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Research Achievements (Oral/Poster Presentations)
Poster presentation  フッ素導入により反応性代謝物の生成を回避した改良型Diclofenac類縁体の創製  日本薬学会第139年会  2019/03/20 
Poster presentation  抗パーキンソン病活性を有するテトラロンアナログB環へのフッ素の導入と神経細胞保護効果  日本薬学会第139年会  2019/03/20 
Poster presentation  HIVプロテアーゼおよび逆転写酵素阻害活性を有する新規多標的型C60誘導体の創製:基質遷移状態模倣型イソスターとC60コアを結ぶリンカーの長さの検討  日本薬学会第139年会  2019/03/20 
Poster presentation  ハードな反応性代謝物を捕捉する新規蛍光標識化トラッピング剤の創製  日本薬学会第139年会  2019/03/20 
Oral presentation(general)  オキシカム構造を模倣したスルホン類の抗パーキンソン病効果  日本薬学会第139年会  2019/03/20 
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Memberships in Academic Societies
酸化ストレス学会 
有機合成化学協会 
日本薬学会 
日本化学会 
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  Link to KOARA(Japanese Only) About KOARA(KeiO Associated Repository of Academic resources)(Japanese Only)
  About KOARA(KeiO Associated Repository of Academic resources)(Japanese Only)