日本語
KEIO UNIVERSITY 
Faculty of Pharmacy 
Department of Pharmacy 

Senior Assistant Professor / Assistant Professor 
KATAYAMA Kazuhiro 

 

Career
Kyoritsu University of Pharmacy  Division of Chemotherapy  Assistant Professor  2005/04/01-2007/03/31 
Kyoritsu University of Pharmacy  DIvision of Chemotherapy  Assistant Professor  2007/04/01-2008/03/31 
Keio University  Faculty of Pharmacy, Division of Chemotherapy  Assistant Professor  2008/04/01-2010/03/31 
NCI/NIH  Laboratory of Cell Biology  Visiting Scientist  2008/09-2009/08 
Keio University  Faculty of Pharmacy, Division of Chemotherapy  Senior Assistant Professor  2010/04/01-Present 

Academic Background
Kitasato University  薬学部  薬学科  1999/03/22  Graduated 
Kitasato University  Graduate School, Division of Medical Sciences  Tumor Pathology  Master's course  2001/03/26  Completed 
The University of Tokyo  Graduate School, Division of Medical Sciences  Molecular Cellular Biology  Doctoral course  2005/03/24  Completed 

Academic Awards
Incitement Award of the Japanese Association for Molecular Target Therapy of Cancer  Clarification of the expressional regulation of ABC transporters  2015/06/11 
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Licenses and Qualifications
薬剤師免許  1999/06/11 

Research Areas
Molecular biology 
Cell biology 
Medical pharmacy 

Research Themes
Regulation of ABC transporter expression  2005/04/01-Present 

Funded Research Projects (Competitive Research Funds, etc.)
Basic research for development of new drugs based on the regulation of ABC transporters activity and expression  Research grant  Japan society for the promotion of science  Grant-in-Aid for Scientific Research  2011/04/01-2013/03/31  P-glycoprotein (P-gp) is a member of the ABC transporters and transports several anticancer drugs. Overexpression of P-gp in cancer cells contributes resistance to the anticancer agents. This study aimed to clarify the mechanisms of P-gp expression and activation, and the following mechanisms were found: (1) P-gp was recognized by SCFFBX15, ubiquitinated by Ube2r1/Cdc34/Ubc3 and then degraded by the proteasome; (2) expression of the protein dephosphorylation complex PP5/PPP2R3C lowered P-gp expression. 
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Research Achievements (Books)
癌治療の新たな試み.  片山和浩, 藤田直也, 鶴尾隆.  142-154  大阪/医薬ジャーナル社  2005/12 
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Research Achievements (Original Articles and Commentaries)
Research paper (scholarly journal)  Joint  Protein kinase C alpha-mediated phosphorylation of PIM-1L promotes the survival and proliferation of acute myeloid leukemia cells.  Takami M, Katayama K, Noguchi K, Sugimoto Y.  Biochem Biophys Res Commun.  Elsevier  503/ 3, 1364-1371  2018/09/10  10.1016/j.bbrc.2018.07.049 
Research paper (scholarly journal)  Synthesis of 5-Hydroxy-3',4',7-trimethoxyflavone (HTMF) and Related Compounds and Elucidation of Their Reversal Effects on BCRP/ABCG2-Mediated Anticancer Drug Resistance.  Tsunekawa R, Katayama K, Hanaya K, Higashibayashi S, Sugimoto Y, Sugai T.  ChemBioChem  Wiley Online Library  2018/09/06  10.1002/cbic.201800431 
Research paper (scholarly journal)  Joint  Heat shock protein 90 inhibitors overcome the resistance to Fms-like tyrosine kinase 3 inhibitors in acute myeloid leukemia  Kazuhiro Katayama, Kohji Noguchi, Yoshikazu Sugimoto.  Oncotarget  9/ 76, 34240-34258  2018/08/21  10.18632/oncotarget.26045 
Research paper (scholarly journal)  Joint  IL-10 promoter transactivation by the viral K-RTA protein involves the host-cell transcription factors Specificity Protein 1 and 3.  Miyazawa M, Noguchi K, Kujirai M, Katayama K, Yamagoe S, Sugimoto Y.  J. Biol. Chem.  293/ 2, 662-676  2018/01/12  10.1074/jbc.M117.802900 
Research paper (scholarly journal)  Joint  Functional effects of AKT3 on Aurora kinase inhibitor-induced aneuploidy.  Kohji Noguchi, Keita Hongama, Shiori Hariki, Yuma Nonomiya, Kazuhiro Katayama, Yoshikazu Sugimoto  J. Biol. Chem.  292/ 5, 1910-1924  2017/02/03  10.1074/jbc.M116.747048 
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Research Achievements (Oral/Poster Presentations)
Poster presentation  Olaparib resistant cells are sensitive to other PARP inhibitor, veliparib and rucaparib  The 77th Annual Meeting of the Japanese Cancer Association  2018/09/27 
Poster presentation  Possible role of TNIK in JQ1-resistant HCT 116 cells  The 77th Annual Meeting of the Japanese Cancer Association  2018/09/27 
Oral presentation(general)  HSP90 inhibitor 17-AAG suppresses the proliferation of FLT3- ITD/D835 mutant AML cells  The 77th Annual Meeting of the Japanese Cancer Association  2018/09/27 
Poster presentation  JQ1 耐性細胞における cyclin E1 の発現上昇に対する TNIK の関与  第62回日本薬学会関東支部大会  2018/09/15 
Oral presentation(general)  AKT による染色体分離の制御  第62回日本薬学会関東支部大会  2018/09/15 
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Memberships in Academic Societies
American Association for Cancer Research  2009-Present 
The Pharmaceutical Society of Japan  2006-Present 
The Japanese Association for Molecular Target Therapy of Cnacer  2006-Present 
Japanese Cancer Association  2000-Present 
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  About KOARA(KeiO Associated Repository of Academic resources)(Japanese Only)